The territory of Bisaccia was already inhabited in the X century B.C. the most characteristic places of the village are the Convent, the Ducal Castle, the Cathedral in Piazza Duomo and the church of the dead. In the IX century B.C. the civilization of Oliveto-Cairano, coming from the Adriatic shore and landed in Puglia at the Ofanto and going up the river, founded villages in Cairano and wallet. At Bisaccia and Lacedonia new inhabitants it replaced other of the bronze age. Here they built a necropolis (IX-VIII century B.C.) with ditch tombs and tombs of the iron age that validates the ancient origins of his sack.
In the following, according to the tradition, the Samnites built on the place where it stands now Bisaccia The ancient city of Romulea, where concentrated their more wealth. The city remained in the hands of sannita up to 296 a.C., year in which was attacked and looted by the Romans. The Irpini, including the inhabitants of Romulea, wishing to regain its independence from Rome, rebelled several times to the Roman Republic, allying themselves with the Tarantini of Pyrrhus and the Carthaginians of Hannibal. After the defeat of Capua imposed on them by the Romans, the Irpini were reduced to silence and punished.
After the wars against Pirro the Romans to take under observation the Irpini, built an arx (presidium) Romulea, on the ruins of the oppidum destroyed in 296 B.C. The name Bisaccia could derive from the name of this Roman garrison (Bis arx) or from bis acta (made twice). In the Augustan age was made a Roman colony at Romulea, the so-called romulensis Cologne.
In 591 the Lombards conquered the Irpinia and wallet until the arrival of the Normans who, guided by Roberto d'Altavilla said il Guiscardo (i.e. the astute), soggiogò the entire area. In 1246 the Lord at Bisaccia Riccardo di Bisaccia was deprived of his fief by Emperor Frederick II as guilty of having participated in the conspiracy of Capaccio. The castle was rebuilt by Frederick II, who used it as a prison and visited Bisaccia in 1250. According to the local tradition, Federico II would have used the castello di Bisaccia as hunting residence and it would also have been occasional seat of the school Sicilian Poetry.
From the XV-XVI century until 1861 Bisaccia became part of the Kingdom of Naples (then become the Kingdom of the Two Sicilies in 1815), which from 1501 to 1707 was of Spanish dominion. Hosted in the course of the centuries also writers as Torquato Tasso (1588) and Francesco De Sanctis. In 1707 the Spanish viceroy Ascalona was defeated by the Austrians who took possession of the Duchy of Naples and made prisoners the duke of Bisaccia, the viceroy and other noble. Between 1731 and 1739 Austria was involved in the Polish war of succession in the course of which lost the kingdom of Naples and Sicily on which settled the Bourbons.
In 1805, the French Emperor Napoleon Bonaparte occupied the Kingdom of Naples, declaring therefore lapsed the Bourbon dynasty. The French Emperor appointed then his brother Joseph King of Naples. Under an administration foreign predominantly,was abolished the feudalism. On 8 March 1809, the eighth duke of Bisaccia John Armando Pignatelli died without heirs; the feud and the title of Duke of Bisaccia were then donated to the royal court.
The Civic Archaeological Museum at Bisaccia is located inside the Ducal Castle and contains in its interior several archaeological finds (tombs and funerary) belonging to the Civilization of Oliveto-Cairano and found in the old cemetery at Bisaccia between 1973 and 1996; among these, of particular importance is the tomb of the princess of his sack.
The vast territory of Bisaccia, since the prehistory, it has always been used as a suitable site for the rearing of cattle and sheep and goats. Since the most remote times was renowned and flourishing the rearing of livestock and the wool industry. At Bisaccia, until the fifties, there were numerous local craftsmen, devoted to the weaving carpets, bed blankets and clothing. At the foot of the ducal castle of Bisaccia is still in activity is the production of fabrics, rugs and much more with finnish frame.
The typical products of the local gastronomy are the treidde (cavatelli bisaccesi), the strufolis (strufele, a typical Christmas cake) and the squarcella (squarcedda), a typical Easter cake.