Cetona is located in the extreme southern slopes of Siena, in Tuscany, almost on the border with Lazio. Its urban physiognomy is that of a small Tuscan village with stone and brickwork. An aspect that rises even further, against the green of the forests of Monte Cetona, which is the fifth in the country.
The Cetona landmark probably derives from an ancient early Christian church, cited in documents such as Sancti Johannis de Queneto or Queteno baptisterium, perhaps referring to the Chieteno torrent that runs to the south. In a text of 1275 this church is reported as a plebs by Sancti Johannis de Scetona. Archaeological finds were found around the city at the Lattaia tomb. It is worth mentioning in the area the medieval village and the church of San Giovanni Battista in Camposervoli, the Civic Museum for the prehistory of Monte Cetona and Villa La Vagnola.
Between the 7th and 6th centuries BC, Etruscan villages are located on the hills of Chiusi and Sarteano. At Cetona the settlement is documented near Camposervoli. In 1207 there is the first mention of the Cetona castle. In 1260 the village passed to the Republic of Orvieto after a long dispute with that of Siena. In 1418 it passed to the Republic of Siena. In 1556, faithful to Siena for nearly a century and a half, the inhabitants, decimated by plagues and wars, surrender without fighting the imperial army in Tuscany when it comes under the walls. The village is thus embedded in the Grand Duchy of Tuscany. In 1558-69, Cetona was given a feud from Grand Duke Cosimo I to the Vitelli family. With the calf marquette begins a golden age for the town. Back in 1770 to become part of the Grand Duchy of Tuscany, it follows its up to the Risorgimento and the unity of Italy.